Title : Characterization of the translation-dependent step during iron-regulated decay of transferrin receptor mRNA.

Pub. Date : 1999 Jun 4

PMID : 10347228






2 Functional Relationships(s)
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1 Inhibition of IRP inactivation by cycloheximide or by the specific proteasome inhibitor MG132 correlated with the stabilization of TfR mRNA. Cycloheximide Wnt family member 2 Homo sapiens
2 These observations suggest that inhibition of translation by cycloheximide interferes with the rate-limiting step of iron-induced TfR mRNA decay in a trans-acting mechanism by blocking IRP inactivation. Cycloheximide Wnt family member 2 Homo sapiens