Pub. Date : 1999 Jun 1
PMID : 10339499
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Constitutive expression of v-Myc blocks phorbol ester (TPA)-induced differentiation of human U-937 monoblasts. | Tetradecanoylphorbol Acetate | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | However, costimulation with interferon-gamma (IFN-gamma) and TPA restores terminal differentiation and G1 cell-cycle arrest despite continuous expression of v-Myc. | Tetradecanoylphorbol Acetate | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | The mechanism by which TPA + IFN-gamma counteract v-Myc activity has not been unravelled. | Tetradecanoylphorbol Acetate | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 4 | Our results show that TPA + IFN-gamma treatment led to an inhibition of v-Myc- and c-Myc-dependent transcription, and a specific reduction of v-Myc:Max complexes and associated DNA-binding activity, whereas the steady state level of the v-Myc protein was only marginally affected. | Tetradecanoylphorbol Acetate | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 5 | Our results show that TPA + IFN-gamma treatment led to an inhibition of v-Myc- and c-Myc-dependent transcription, and a specific reduction of v-Myc:Max complexes and associated DNA-binding activity, whereas the steady state level of the v-Myc protein was only marginally affected. | Tetradecanoylphorbol Acetate | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 6 | Our results show that TPA + IFN-gamma treatment led to an inhibition of v-Myc- and c-Myc-dependent transcription, and a specific reduction of v-Myc:Max complexes and associated DNA-binding activity, whereas the steady state level of the v-Myc protein was only marginally affected. | Tetradecanoylphorbol Acetate | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 7 | Our results show that TPA + IFN-gamma treatment led to an inhibition of v-Myc- and c-Myc-dependent transcription, and a specific reduction of v-Myc:Max complexes and associated DNA-binding activity, whereas the steady state level of the v-Myc protein was only marginally affected. | Tetradecanoylphorbol Acetate | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 8 | Phosphatase treatment of Myc:Max complexes lead to their dissociation, thus mimicking the effect of TPA + IFN-gamma. | Tetradecanoylphorbol Acetate | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |