Pub. Date : 1999 May 28
PMID : 10339403
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, mutation of the serine residue at position 121 of UGT2B17 to a tyrosine, as found in UGT2B15, abolished the ability of UGT2B17 to conjugate androsterone at the 3alpha position, but still retained activity for dihydrotestosterone and 5alpha-androstane-3alpha, 17beta-diol, which have an OH-group at the 17beta position. | Tyrosine | UDP glucuronosyltransferase family 2 member B15 | Homo sapiens |
| 2 | Interestingly, mutation of tyrosine 121 in UGT2B15 to a serine abolished activity for C19steroids. | Tyrosine | UDP glucuronosyltransferase family 2 member B15 | Homo sapiens |
| 3 | It is suggested that the serine residue at position 121 in UGT2B17 is required for activity towards the 3alpha and not for the 17beta position of C19steroids, whereas the tyrosine 121 in UGT2B15 is necessary for UGT activity. | Tyrosine | UDP glucuronosyltransferase family 2 member B15 | Homo sapiens |