Title : Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1).

Pub. Date : 1999 Jun

PMID : 10336536






2 Functional Relationships(s)
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1 Both ACPA and ACEA have the characteristics of agonists at the CB1 receptor; both inhibit forskolin-induced accumulation of cAMP in Chinese hamster ovary cells expressing the human CB1 receptor, and both analogs increase the binding of [35S]GTPgammaS to cerebellar membranes and inhibit electrically evoked contractions of the mouse vas deferens. Colforsin cannabinoid receptor 1 Homo sapiens
2 Both ACPA and ACEA have the characteristics of agonists at the CB1 receptor; both inhibit forskolin-induced accumulation of cAMP in Chinese hamster ovary cells expressing the human CB1 receptor, and both analogs increase the binding of [35S]GTPgammaS to cerebellar membranes and inhibit electrically evoked contractions of the mouse vas deferens. Colforsin cannabinoid receptor 1 Homo sapiens