Title : Betulinic acid-induced apoptosis in glioma cells: A sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing.

Pub. Date : 1999 Jun

PMID : 10336521






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Ectopic expression of BCL-2 prevents BA-induced caspase activation, DNA fragmentation, and cell death. betulinic acid BCL2 apoptosis regulator Homo sapiens
2 The generation of reactive oxygen species is blocked by BCL-2 and requires new protein synthesis but is unaffected by caspase inhibitors, suggesting that BA toxicity sequentially involves new protein synthesis, formation of reactive oxygen species, and activation of crm-A-insensitive caspases. betulinic acid BCL2 apoptosis regulator Homo sapiens