Title : 11beta-hydroxysteroid dehydrogenase in cultured human vascular cells. Possible role in the development of hypertension.

Pub. Date : 1999 May

PMID : 10334808






1 Functional Relationships(s)
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1 We found that physiological concentrations of cortisol-induced increase in angiotensin II binding were significantly enhanced by the inhibition of 11beta-HSD2 activity with an antisense DNA complementary to 11beta-HSD2 mRNA, and the enhancement was partially but significantly abolished by a selective aldosterone receptor antagonist. Hydrocortisone angiotensinogen Homo sapiens