Pub. Date : 1999 Apr
PMID : 10333080
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lactate stimulates insulin secretion without blocking the K+ channels in HIT-T15 insulinoma cells. | Lactic Acid | insulin | Mesocricetus auratus |
| 2 | To clarify the mechanism by which lactate affects insulin secretion, we investigated the effect of lactate on insulin secretion, cytosolic free Ca2+ ([Ca2+](i), the ATP sensitive K+ channel (K(ATP)) and the Ca2+-activated K+ channel (K(Ca)) in HIT-T15 cells, and the results were compared with those of glucose and glibenclamide. | Lactic Acid | insulin | Mesocricetus auratus |
| 3 | Lactate at a concentration of 10 mmol/l activated both the K(ATP) and KCa channels, not only in cell-attached, but also in inside-out patch configurations, indicating that the increase in [Ca2+](i) and secretion of insulin by lactate cannot be explained by the blocking of the K+ channels. | Lactic Acid | insulin | Mesocricetus auratus |
| 4 | Lactate at a concentration of 10 mmol/l activated both the K(ATP) and KCa channels, not only in cell-attached, but also in inside-out patch configurations, indicating that the increase in [Ca2+](i) and secretion of insulin by lactate cannot be explained by the blocking of the K+ channels. | Lactic Acid | insulin | Mesocricetus auratus |