Pub. Date : 1999 Jun
PMID : 10332029
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A novel gene, designated PQBP-1, which encodes a 265 residue protein that binds to the polyglutamine tract of the brain-specific transcription factor Brn-2, was identified. | polyglutamine | polyglutamine binding protein 1 | Rattus norvegicus |
| 2 | PQBP-1, which also interacts with the polyglutamine tract of triplet repeat disease gene products, binds with a higher affinity to an expanded polyglutamine tract. | polyglutamine | polyglutamine binding protein 1 | Rattus norvegicus |
| 3 | PQBP-1, which also interacts with the polyglutamine tract of triplet repeat disease gene products, binds with a higher affinity to an expanded polyglutamine tract. | polyglutamine | polyglutamine binding protein 1 | Rattus norvegicus |
| 4 | PQBP-1 has several functional domains, including hepta- and di-amino acid repeat sequences rich in polar residues essential for its interaction with the polyglutamine tract, a WWP/WW domain which binds to proline-rich motifs in other proteins, a putative nuclear localization signal sequence and a C2domain implicated in Ca2+-dependent phospholipid signaling. | polyglutamine | polyglutamine binding protein 1 | Rattus norvegicus |
| 5 | These results suggest that PQBP-1 mediates important cellular functions under physiological and pathological conditions via its interaction with polyglutamine tracts. | polyglutamine | polyglutamine binding protein 1 | Rattus norvegicus |