Title : Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates alkylation-induced shuttle-vector mutagenesis in Chinese hamster cells.

Pub. Date : 1999 Mar

PMID : 10331635






1 Functional Relationships(s)
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1 We could show that dexamethasone-induced overexpression of the PARP DNA-binding domain in COM3 cells potentiates the mutagenicity of the alkylating agent N-methyl-N-nitrosourea, while no effect of dexamethasone treatment on mutation frequency was recorded in control cells lacking the PARP DNA-binding domain transgene. Methylnitrosourea poly (ADP-ribose) polymerase family, member 1 Mus musculus