Title : Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors.

Pub. Date : 1999 Apr 19

PMID : 10328307






1 Functional Relationships(s)
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1 Recently in the synthesis of selective COX-2 inhibitors we have discovered that the sulfonamide moiety is a suitable replacement for the methylsulfonyl moiety yielding compounds with activity both in vitro and in vivo. methylsulfonyl mitochondrially encoded cytochrome c oxidase II Homo sapiens