Title : Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases.

Pub. Date : 1999 May 14

PMID : 10318809






1 Functional Relationships(s)
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1 In PC12 rat pheochromocytoma cells, both agents block lysophosphatidic acid (LPA)- and bradykinin-stimulated Erk 1/2 phosphorylation, suggesting that intact focal adhesion complexes are required for GPCR-induced mitogen-activated protein kinase activation in these cells. lysophosphatidic acid mitogen activated protein kinase 3 Rattus norvegicus