Pub. Date : 1999 Feb
PMID : 10233691
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Granulocyte-macrophage colony-stimulating factor and interleukin-3 cause basophil histamine release by a common pathway: downregulation by sodium. | Histamine | interleukin 3 | Homo sapiens |
| 2 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) are recognized as enhancers, but not as inducers, of histamine release from normal human basophils. | Histamine | interleukin 3 | Homo sapiens |
| 3 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) are recognized as enhancers, but not as inducers, of histamine release from normal human basophils. | Histamine | interleukin 3 | Homo sapiens |
| 4 | However, when extracellular Na+ is removed IL-3 acquires the capacity to induce histamine release. | Histamine | interleukin 3 | Homo sapiens |
| 5 | However, when extracellular Na+ was substituted iso-osmotically with N-methyl-d-glucamine+ or with choline+, GM-CSF and IL-3 were able to trigger histamine release from either mixed leucocyte suspensions or purified human basophils. | Histamine | interleukin 3 | Homo sapiens |
| 6 | The kinetics of IL-3-induced histamine release were similar, whereas anti-IgE-induced histamine release was more rapid, being almost maximal after incubation for 30 min. | Histamine | interleukin 3 | Homo sapiens |
| 7 | A good correlation was found between GM-CSF-induced and IL-3-induced histamine release; furthermore, the combined effects of the two cytokines were less than additive, suggesting that they share the same pathways leading to histamine release. | Histamine | interleukin 3 | Homo sapiens |
| 8 | When extracellular Na+ concentration was increased from 0 to 140 mm, histamine release induced by GM-CSF, IL-3 and anti-IgE was reduced progressively. | Histamine | interleukin 3 | Homo sapiens |
| 9 | These results provide indirect evidence that GM-CSF and IL-3 can induce basophil histamine release by a common pathway that is downregulated by Na+. | Histamine | interleukin 3 | Homo sapiens |