Pub. Date : 1999 Apr
PMID : 10233213
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ticlopidine decreases the in vivo activity of CYP2C19 as measured by omeprazole metabolism. | Ticlopidine | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |
| 2 | AIMS: To examine the effect of ticlopidine administration on the activities CYP2C19 and CYP3 A in vivo using omeprazole as a model substrate. | Ticlopidine | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |
| 3 | CONCLUSIONS: These findings suggest that ticlopidine inhibited the in vivo activity of CYP2C19, but not, or to a lesser extent CYP3 A4, and that the magnitude of inhibition by ticlopidine is related to the in vivo activity of CYP2C19 before inhibition. | Ticlopidine | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |
| 4 | CONCLUSIONS: These findings suggest that ticlopidine inhibited the in vivo activity of CYP2C19, but not, or to a lesser extent CYP3 A4, and that the magnitude of inhibition by ticlopidine is related to the in vivo activity of CYP2C19 before inhibition. | Ticlopidine | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |
| 5 | CONCLUSIONS: These findings suggest that ticlopidine inhibited the in vivo activity of CYP2C19, but not, or to a lesser extent CYP3 A4, and that the magnitude of inhibition by ticlopidine is related to the in vivo activity of CYP2C19 before inhibition. | Ticlopidine | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |
| 6 | CONCLUSIONS: These findings suggest that ticlopidine inhibited the in vivo activity of CYP2C19, but not, or to a lesser extent CYP3 A4, and that the magnitude of inhibition by ticlopidine is related to the in vivo activity of CYP2C19 before inhibition. | Ticlopidine | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |