Pub. Date : 1999 May
PMID : 10231362
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metabolic studies using recombinant escherichia coli cells producing rat mitochondrial CYP24 CYP24 can convert 1alpha,25-dihydroxyvitamin D3 to calcitroic acid. | Calcitriol | cytochrome P450, family 24, subfamily a, polypeptide 1 | Rattus norvegicus |
| 2 | Metabolic studies using recombinant escherichia coli cells producing rat mitochondrial CYP24 CYP24 can convert 1alpha,25-dihydroxyvitamin D3 to calcitroic acid. | Calcitriol | cytochrome P450, family 24, subfamily a, polypeptide 1 | Rattus norvegicus |
| 3 | In this study, we demonstrate further oxidation by CYP24 including four- and six-step monooxygenation towards 25-hydroxyvitamin D3 and 1alpha,25-dihydroxyvitamin D3, respectively. | Calcitriol | cytochrome P450, family 24, subfamily a, polypeptide 1 | Rattus norvegicus |
| 4 | Furthermore, in-vivo and in-vitro metabolic studies on 1alpha,25-dihydroxyvitamin D3 clearly indicated that CYP24 catalyses six-step monooxygenation to convert 1alpha,25-dihydroxyvitamin D3 into calcitroic acid which is known as a final metabolite of 1alpha,25-dihydroxyvitamin D3 for excretion in bile. | Calcitriol | cytochrome P450, family 24, subfamily a, polypeptide 1 | Rattus norvegicus |
| 5 | Furthermore, in-vivo and in-vitro metabolic studies on 1alpha,25-dihydroxyvitamin D3 clearly indicated that CYP24 catalyses six-step monooxygenation to convert 1alpha,25-dihydroxyvitamin D3 into calcitroic acid which is known as a final metabolite of 1alpha,25-dihydroxyvitamin D3 for excretion in bile. | Calcitriol | cytochrome P450, family 24, subfamily a, polypeptide 1 | Rattus norvegicus |
| 6 | Furthermore, in-vivo and in-vitro metabolic studies on 1alpha,25-dihydroxyvitamin D3 clearly indicated that CYP24 catalyses six-step monooxygenation to convert 1alpha,25-dihydroxyvitamin D3 into calcitroic acid which is known as a final metabolite of 1alpha,25-dihydroxyvitamin D3 for excretion in bile. | Calcitriol | cytochrome P450, family 24, subfamily a, polypeptide 1 | Rattus norvegicus |
| 7 | These results strongly suggest that CYP24 is largely responsible for the metabolism of both 25-hydroxyvitamin D3 and 1alpha,25-dihydroxyvitamin D3. | Calcitriol | cytochrome P450, family 24, subfamily a, polypeptide 1 | Rattus norvegicus |