Title : A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro.

Pub. Date : 1999 Mar

PMID : 10219967






1 Functional Relationships(s)
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1 Induction of CYP3A4-dependent reporter gene expression and enhancement of the induction by the glucocorticoid receptor was also observed with pregnenolone-16alpha-carbonitrile (PCN), rifampicin, phenytoin, carbamazepine, phenylbutazone and phenobarbitone, all known in vivo inducers of CYP3A4 in man. Phenobarbital cytochrome P450 family 3 subfamily A member 4 Homo sapiens