Title : Effect of tumor necrosis factor-alpha on insulin signal transduction in rat adipocytes: relation to PKCbeta and zeta translocation.

Pub. Date : 1999 Apr 1

PMID : 10209302






3 Functional Relationships(s)
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1 Pretreatment with 0.1-100 nM TNF-alpha for 60 min resulted in a significant decrease in 10 nM insulin- or 1 microM 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced [3H]2-deoxyglucose uptake without affecting basal glucose uptake. Tetradecanoylphorbol Acetate tumor necrosis factor Rattus norvegicus
2 Pretreatment with 0.1-100 nM TNF-alpha for 60 min resulted in a significant decrease in 10 nM insulin- or 1 microM 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced [3H]2-deoxyglucose uptake without affecting basal glucose uptake. Tetradecanoylphorbol Acetate tumor necrosis factor Rattus norvegicus
3 10 nM TNF-alpha pretreatment also suppressed 10 nM insulin- and 1 microM TPA-induced increases in membrane-associated PKCbeta and PKCzeta. Tetradecanoylphorbol Acetate tumor necrosis factor Rattus norvegicus