Title : IL-3 and IL-4 activate cyclic nucleotide phosphodiesterases 3 (PDE3) and 4 (PDE4) by different mechanisms in FDCP2 myeloid cells.

Pub. Date : 1999 Apr 15

PMID : 10202031






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 IL-4 (not IL-3 or GM-CSF) induced tyrosine phosphorylation of insulin-receptor substrate-2 (IRS-2) and its association with phosphatidylinositol 3-kinase (PI3-K). Tyrosine interleukin 4 Mus musculus
2 TNF-alpha also blocked IL-4-induced tyrosine phosphorylation of IRS-2, but not of STAT6. Tyrosine interleukin 4 Mus musculus
3 These results suggested that IL-4-induced activation of PDE3 and PDE4 was downstream of IRS-2/PI3-K, not STAT6, and that inhibition of tyrosine phosphorylation of IRS molecules might be one mechnism whereby TNF-alpha could selectively regulate activities of cytokines that utilized IRS proteins as signal transducers. Tyrosine interleukin 4 Mus musculus