Title : Alpha interferon inhibits human herpesvirus 8 (HHV-8) reactivation in primary effusion lymphoma cells and reduces HHV-8 load in cultured peripheral blood mononuclear cells.

Pub. Date : 1999 May

PMID : 10196299






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 IFN-alpha inhibited in a dose-dependent manner the amplification of HHV-8 DNA in BCBL-1 cells induced to lytic infection with tetradecanoyl phorbol acetate (TPA). Tetradecanoylphorbol Acetate interferon alpha 1 Homo sapiens
2 IFN-alpha inhibited in a dose-dependent manner the amplification of HHV-8 DNA in BCBL-1 cells induced to lytic infection with tetradecanoyl phorbol acetate (TPA). Tetradecanoylphorbol Acetate interferon alpha 1 Homo sapiens
3 Conversely, the addition of anti-IFN-alpha Ab to TPA-induced BCBL-1 cells resulted in a larger number of mature enveloped particles and in a more extensive cytopathic effect due to the neutralization of the endogenous IFN produced by these cells. Tetradecanoylphorbol Acetate interferon alpha 1 Homo sapiens
4 Conversely, the addition of anti-IFN-alpha Ab to TPA-induced BCBL-1 cells resulted in a larger number of mature enveloped particles and in a more extensive cytopathic effect due to the neutralization of the endogenous IFN produced by these cells. Tetradecanoylphorbol Acetate interferon alpha 1 Homo sapiens