Pub. Date : 1999 Mar
PMID : 10193676
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lignocaine is metabolized by cytochrome P450 3A4 enzyme (CYP3A4), and has a moderate to high extraction ratio resulting in oral bioavailability of 30%. | Lidocaine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Lignocaine is metabolized by cytochrome P450 3A4 enzyme (CYP3A4), and has a moderate to high extraction ratio resulting in oral bioavailability of 30%. | Lidocaine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | We have studied the possible effect of two inhibitors of CYP3A4, erythromycin and itraconazole, on the pharmacokinetics of oral lignocaine in nine volunteers using a cross-over study design. | Lidocaine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The extent of the interaction of lignocaine with these CYP3A4 inhibitors was, however, less than that of, e.g. midazolam or buspirone, and it did not correlate with the CYP3A4 inhibiting potency of erythromycin and itraconazole. | Lidocaine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |