Pub. Date : 1999 Apr
PMID : 10102293
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: Cultured hRPE cells were treated with different concentrations of a chemical oxidant, t-butylhydroperoxide (tBH), for different periods of time. | tert-Butylhydroperoxide | ribulose-5-phosphate-3-epimerase | Homo sapiens |
| 2 | METHODS: Cultured hRPE cells were treated with different concentrations of a chemical oxidant, t-butylhydroperoxide (tBH), for different periods of time. | tert-Butylhydroperoxide | ribulose-5-phosphate-3-epimerase | Homo sapiens |
| 3 | RESULTS: t-Butylhydroperoxide caused time- and dose-dependent activation of apoptosis in hRPE, indicated by characteristic morphologic changes; TUNEL-positive labeling; phosphatidylserine (PS) exposure; and procaspase 3, poly(ADP-ribose)polymerase, lamin, and tubulin cleavage. | tert-Butylhydroperoxide | ribulose-5-phosphate-3-epimerase | Homo sapiens |
| 4 | CONCLUSIONS: Results indicate that tBH can induce apoptosis in hRPE, probably by triggering the mitochondrial permeability transition, which results in swelling and release of mitochondrial intermembrane proteins. | tert-Butylhydroperoxide | ribulose-5-phosphate-3-epimerase | Homo sapiens |