Title : Thyrotropin regulates c-Jun N-terminal kinase (JNK) activity through two distinct signal pathways in human thyroid cells.

Pub. Date : 1999 Apr

PMID : 10098509






2 Functional Relationships(s)
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1 We next elucidated the signal transduction pathways in TSH-induced JNK activation by examining the involvement of four distinct intracellular signal molecules; protein kinase C (PKC), cAMP, Ca2+, and PI3-kinase. Cyclic AMP mitogen-activated protein kinase 8 Homo sapiens
2 These findings demonstrate that TSH regulates JNK activity biphasically in human thyroid cells through an interaction between Gi-PKC and cAMP-PKA pathways. Cyclic AMP mitogen-activated protein kinase 8 Homo sapiens