Pub. Date : 1999 Apr 10
PMID : 10094816
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of p21(CIP1/Waf1) and activation of p34(cdc2) involved in retinoic acid-induced apoptosis in human hepatoma Hep3B cells. | Tretinoin | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 2 | Induction of p21(CIP1/Waf1) and activation of p34(cdc2) involved in retinoic acid-induced apoptosis in human hepatoma Hep3B cells. | Tretinoin | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 3 | This RA-induced apoptosis was accompanied by p53-independent up-regulation of endogenous p21(CIPI/Waf1) and Bax proteins, as well as activation of p34(cdc2) kinase, and increase of Rb2 protein level and phosphorylation pattern. | Tretinoin | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 4 | This RA-induced apoptosis was accompanied by p53-independent up-regulation of endogenous p21(CIPI/Waf1) and Bax proteins, as well as activation of p34(cdc2) kinase, and increase of Rb2 protein level and phosphorylation pattern. | Tretinoin | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 5 | Furthermore, antisense oligonucleotide complementary to p21(CIP2/Waf1) and p34(cdc2) mRNA significantly rescued RA-induced apoptosis. | Tretinoin | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 6 | Furthermore, antisense oligonucleotide complementary to p21(CIP2/Waf1) and p34(cdc2) mRNA significantly rescued RA-induced apoptosis. | Tretinoin | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 7 | These findings suggest that inappropriate regulation of the cell cycle regulators p21(CIP2/Waf1) and p34(cdc2) is coupled with induction of Bax and involved in cell death with apoptosis when Hep3B cells are exposed to RA. | Tretinoin | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 8 | These findings suggest that inappropriate regulation of the cell cycle regulators p21(CIP2/Waf1) and p34(cdc2) is coupled with induction of Bax and involved in cell death with apoptosis when Hep3B cells are exposed to RA. | Tretinoin | cyclin dependent kinase inhibitor 1A | Homo sapiens |