Title : Angiogenic capacity and lung-colonizing potential in vivo is increased in weakly metastatic B16F1 cells and decreased in highly metastatic BL6 cells by phorbol esters.

Pub. Date : 1998 Jul

PMID : 10091935






3 Functional Relationships(s)
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1 TPA-treated B16F1 cells showed enhanced release of basic FGF (bFGF) and vascular endothelial growth factor (VEGF) and increased angiogenic capacity and lung colony formation in vivo. Tetradecanoylphorbol Acetate fibroblast growth factor 2 Mus musculus
2 TPA-treated B16F1 cells showed enhanced release of basic FGF (bFGF) and vascular endothelial growth factor (VEGF) and increased angiogenic capacity and lung colony formation in vivo. Tetradecanoylphorbol Acetate fibroblast growth factor 2 Mus musculus
3 However, both cell lines showed an induction of VEGF as well as bFGF expression by TPA treatment suggesting that in BL6 cells antagonistic factors, inhibiting the angiogenic and metastatic capacity, are induced by this treatment. Tetradecanoylphorbol Acetate fibroblast growth factor 2 Mus musculus