Pub. Date : 1999 Apr 1
PMID : 10090924
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The downmodulation of CXCR1 and CXCR2 by LPS and TNF-alpha was most dramatically inhibited by metalloproteinase inhibitors; 1, 10-phenanthroline and EDTA significantly attenuated LPS- and TNF-alpha-induced loss of CXCR1 and CXCR2 cell surface expression. | 1,10-phenanthroline | tumor necrosis factor | Homo sapiens |
2 | In addition, while treatment of neutrophils with LPS and TNF-alpha inhibited IL-8 receptor-mediated calcium mobilization and IL-8-directed neutrophil chemotaxis, both 1, 10-phenanthroline and EDTA blocked these inhibitory processes. | 1,10-phenanthroline | tumor necrosis factor | Homo sapiens |