Title : Phospholipase A2 inhibitors and leukotriene synthesis inhibitors block TNF-induced NF-kappaB activation.

Pub. Date : 1999 Feb

PMID : 10089130






1 Functional Relationships(s)
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1 The cellular effects exerted by TNF depend, apart from NF-kappaB-directed gene transcription, largely on its ability to activate phospholipase A2(PLA2), yielding the release of arachidonic acid (AA) and its metabolites. Arachidonic Acid tumor necrosis factor Homo sapiens