Pub. Date : 1999 Apr
PMID : 10086995
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | An enhanced gene transcription is the most likely mechanism involved in the tretinoin-induced stimulation of MC antioxidant defense systems because 1) preincubation of MCs with actinomycin D or cycloheximide fully abolished it; 2) tretinoin-incubated MCs showed increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis; and 3) the stability of both mRNA was unchanged by tretinoin. | Cycloheximide | catalase | Rattus norvegicus |