Title : Functional production and reconstitution of the human equilibrative nucleoside transporter (hENT1) in Saccharomyces cerevisiae. Interaction of inhibitors of nucleoside transport with recombinant hENT1 and a glycosylation-defective derivative (hENT1/N48Q).

Pub. Date : 1999 Apr 1

PMID : 10085223






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Dilazep and dipyridamole inhibited NBMPR binding to hENT1 with IC50 values of 130+/-10 and 380+/-20 nM respectively. Dilazep solute carrier family 29 member 1 (Augustine blood group) Homo sapiens
2 These results indicated that the conservative conversion of an Asn residue into Gln at position 48 of hENT1 and/or the loss of N-linked glycosylation capability altered the binding characteristics of the transporter for NBMPR, dilazep and dipyridamole. Dilazep solute carrier family 29 member 1 (Augustine blood group) Homo sapiens