Title : Tyrosine kinase inhibitors as antiproliferative agents against an estrogen-dependent breast cancer cell line in vitro.

Pub. Date : 1999 Feb

PMID : 10084649






4 Functional Relationships(s)
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1 This E2-mediated growth stimulation was completely inhibited (cytostatic effects) by the epidermal growth factor receptor (EGFR)-selective tyrphostins A47, B48, RG13022, and B50. Tyrphostins epidermal growth factor receptor Homo sapiens
2 This E2-mediated growth stimulation was completely inhibited (cytostatic effects) by the epidermal growth factor receptor (EGFR)-selective tyrphostins A47, B48, RG13022, and B50. Tyrphostins epidermal growth factor receptor Homo sapiens
3 CONCLUSIONS: Of the agents tested, only EGFR-selective tyrphostins blocked E2-stimulated tumor cell proliferation, as opposed to the PDGFR-selective tyrphostin, RTK noninhibitory agent, or the phytoestrogen, genistein, which did not exert such an effect. Tyrphostins epidermal growth factor receptor Homo sapiens
4 CONCLUSIONS: Of the agents tested, only EGFR-selective tyrphostins blocked E2-stimulated tumor cell proliferation, as opposed to the PDGFR-selective tyrphostin, RTK noninhibitory agent, or the phytoestrogen, genistein, which did not exert such an effect. Tyrphostins epidermal growth factor receptor Homo sapiens