Pub. Date : 1999 Mar
PMID : 10082496
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Administration of bradykinin or its ACE-resistant analogue desensitized the receptor, but it was resensitized (arachidonic acid release or [Ca2+]i mobilization) by agents such as enalaprilat (1 micromol/L). | Enalaprilat | kininogen 1 | Homo sapiens |
| 2 | Enalaprilat resensitized the receptor via ACE to release arachidonic acid by bradykinin at a lower concentration (5 nmol/L) than required to mobilize [Ca2+]i (1 micromol/L). | Enalaprilat | kininogen 1 | Homo sapiens |
| 3 | Enalaprilat potentiated the bradykinin effect in cells expressing a mutant ACE with a single N-domain active site. | Enalaprilat | kininogen 1 | Homo sapiens |