Pub. Date : 1999 Mar 4
PMID : 10078537
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sildenafil is a selective inhibitor of phosphodiesterase type 5 (PDE5), which has been shown to be a clinically effective treatment for erectile dysfunction. | Sildenafil Citrate | phosphodiesterase 5A | Homo sapiens |
| 2 | Sildenafil is a selective inhibitor of phosphodiesterase type 5 (PDE5), which has been shown to be a clinically effective treatment for erectile dysfunction. | Sildenafil Citrate | phosphodiesterase 5A | Homo sapiens |
| 3 | The distribution of PDE5 in the cardiovascular system is consistent with the observed pharmacodynamic and clinical effects of sildenafil. | Sildenafil Citrate | phosphodiesterase 5A | Homo sapiens |
| 4 | Sildenafil selectively increased cGMP levels in coronary vascular smooth muscle tissue but produced no change in cyclic adenosine monophosphate (cAMP) levels, which is consistent with the drug"s selectivity for PDE5. | Sildenafil Citrate | phosphodiesterase 5A | Homo sapiens |
| 5 | Human platelets were found to contain PDE5, which was inhibited by 50% (IC50) by sildenafil at a concentration of 6.3 nM, consistent with the IC50 value in the corpus cavernosum. | Sildenafil Citrate | phosphodiesterase 5A | Homo sapiens |
| 6 | The pharmacodynamic and adverse event profiles observed in clinical trials with sildenafil are consistent with the in vitro profile of the tissue distribution of PDE5 and its known mechanism of action as a selective inhibitor of PDE5. | Sildenafil Citrate | phosphodiesterase 5A | Homo sapiens |
| 7 | The pharmacodynamic and adverse event profiles observed in clinical trials with sildenafil are consistent with the in vitro profile of the tissue distribution of PDE5 and its known mechanism of action as a selective inhibitor of PDE5. | Sildenafil Citrate | phosphodiesterase 5A | Homo sapiens |