Pub. Date : 1999 Mar
PMID : 10070078
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCA-salt-hypertensive rats. | Desoxycorticosterone Acetate | 5-hydroxytryptamine receptor 2B | Rattus norvegicus |
| 2 | We hypothesized that the 5-HT2B receptor may play a role in maintaining the high blood pressure of DOCA-salt-hypertensive rats, and herein we provide data connecting in vitro and in vivo findings. | Desoxycorticosterone Acetate | 5-hydroxytryptamine receptor 2B | Rattus norvegicus |
| 3 | The endothelium-denuded isolated superior mesenteric artery of DOCA-salt rats displayed a marked increase in maximum contraction to the newly available 5-HT2B-receptor agonist BW-723C86 compared with that of arteries from sham rats, confirming that the 5-HT2B receptor plays a greater role in 5-HT-induced contraction in arteries from DOCA-salt rats. | Desoxycorticosterone Acetate | 5-hydroxytryptamine receptor 2B | Rattus norvegicus |
| 4 | The endothelium-denuded isolated superior mesenteric artery of DOCA-salt rats displayed a marked increase in maximum contraction to the newly available 5-HT2B-receptor agonist BW-723C86 compared with that of arteries from sham rats, confirming that the 5-HT2B receptor plays a greater role in 5-HT-induced contraction in arteries from DOCA-salt rats. | Desoxycorticosterone Acetate | 5-hydroxytryptamine receptor 2B | Rattus norvegicus |
| 5 | These data support the novel hypothesis that 5-HT2B-receptor expression is induced during the development of DOCA-salt hypertension and contributes to the maintenance of severe blood pressure elevations. | Desoxycorticosterone Acetate | 5-hydroxytryptamine receptor 2B | Rattus norvegicus |