Title : Signal transduction pathways involved in the synergistic stimulation of prostaglandin production by interleukin-1beta and tumor necrosis factor alpha in human gingival fibroblasts.

Pub. Date : 1999 Jan

PMID : 10065947






1 Functional Relationships(s)
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1 The phospholipase A2 (PLA2) inhibitor, BPB, and the PKC inhibitor, BIS, reduced PGE2 production, whereas dexamethasone, indomethacin, and NS-398 completely abolished PGE2 production induced by IL-1beta, TNFalpha, and the combination. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide tumor necrosis factor Homo sapiens