Title : Diesel exhaust particulates upregulate histamine receptor mRNA and increase histamine-induced IL-8 and GM-CSF production in nasal epithelial cells and endothelial cells.

Pub. Date : 1999 Jan

PMID : 10051702






2 Functional Relationships(s)
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1 The amount of IL-8 and GM-CSF, induced by histamine, was significantly higher in DEP extract pretreated HNECs and HMMECs than nontreated HNECs and HMMECs. Histamine colony stimulating factor 2 Homo sapiens
2 CONCLUSION: These results strongly suggest that DEP accelerates the inflammatory change by not only directly upregulating H1R expression but also increasing histamine-induced IL-8 and GM-CSF production. Histamine colony stimulating factor 2 Homo sapiens