Title : Human red blood cell acetylcholinesterase inhibition as the appropriate and conservative surrogate endpoint for establishing chlorpyrifos reference dose.

Pub. Date : 1999 Feb

PMID : 10051415






4 Functional Relationships(s)
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1 Human red blood cell acetylcholinesterase inhibition as the appropriate and conservative surrogate endpoint for establishing chlorpyrifos reference dose. Chlorpyrifos acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Basing an acceptable level of human exposure (e.g., RfD) on inhibition of RBC AChE provides a significant margin of safety, since it is 12- to 14-fold more sensitive as an indicator of chlorpyrifos exposure than the AChE in the most sensitive relevant neurological tissues (brain or retina). Chlorpyrifos acetylcholinesterase (Cartwright blood group) Homo sapiens
3 Inhibition of RBC AChE activity is consistently exhibited at lower dosages of chlorpyrifos than those required to result in clinical symptoms of OP toxicity, or alterations in cognitive functional responses. Chlorpyrifos acetylcholinesterase (Cartwright blood group) Homo sapiens
4 Thus, inhibition of RBC AChE activity is an appropriate surrogate measurement of chlorpyrifos exposure and provides a conservative endpoint for establishing appropriate margins of safety for both adults and infants. Chlorpyrifos acetylcholinesterase (Cartwright blood group) Homo sapiens