Title : Thrombopoietin-induced conformational change in p53 lies downstream of the p44/p42 mitogen activated protein kinase cascade in the human growth factor-dependent cell line M07e.

Pub. Date : 1999 Feb 18

PMID : 10050883






3 Functional Relationships(s)
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1 In an effort to identify potential signaling cascades through which Tpo illicits these effects on p53, we report here that treating M07e cells with MAPK kinase inhibitor PD98059 dramatically suppressed Tpo-induced conformational change in p53 as well as Tpo-enhanced viability in M07e cells in a p53-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one tumor protein p53 Homo sapiens
2 In an effort to identify potential signaling cascades through which Tpo illicits these effects on p53, we report here that treating M07e cells with MAPK kinase inhibitor PD98059 dramatically suppressed Tpo-induced conformational change in p53 as well as Tpo-enhanced viability in M07e cells in a p53-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one tumor protein p53 Homo sapiens
3 In an effort to identify potential signaling cascades through which Tpo illicits these effects on p53, we report here that treating M07e cells with MAPK kinase inhibitor PD98059 dramatically suppressed Tpo-induced conformational change in p53 as well as Tpo-enhanced viability in M07e cells in a p53-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one tumor protein p53 Homo sapiens