Title : Mechanism of Ret activation by a mutation at aspartic acid 631 identified in sporadic pheochromocytoma.

Pub. Date : 1999 Feb 24

PMID : 10049754






3 Functional Relationships(s)
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1 The D631Y mutation activated Ret by inducing its disulfide-linked dimerization in the transfectant as observed for multiple endocrine neoplasia (MEN) 2A mutations at cysteine 609, 611, 618, 620, 630, or 634. Disulfides ret proto-oncogene Homo sapiens
2 The D631Y mutation activated Ret by inducing its disulfide-linked dimerization in the transfectant as observed for multiple endocrine neoplasia (MEN) 2A mutations at cysteine 609, 611, 618, 620, 630, or 634. Disulfides ret proto-oncogene Homo sapiens
3 Further mutation analysis suggested that cysteine 630 or 634 could be involved in the disulfide-linked Ret dimerization induced by the D631Y mutation. Disulfides ret proto-oncogene Homo sapiens