Pub. Date : 1999 Mar
PMID : 10049283
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The spirochete Borrelia burgdorferi was unexpectedly found to be as susceptible to diacetyl chloramphenicol, the product of the enzyme chloramphenicol acetyltransferase, as it was to chloramphenicol itself. | Chloramphenicol | chloramphenicol acetyltransferase | Escherichia coli |
| 2 | In the presence of 10% rabbit serum, a strain of E. coli bearing the chloramphenicol acetyltransferase (cat) gene had a fourfold-lower resistance to chloramphenicol than in the absence of serum. | Chloramphenicol | chloramphenicol acetyltransferase | Escherichia coli |
| 3 | These studies indicate that esterases of serum can convert diacetyl chloramphenicol back to an active antibiotic, and thus, in vitro findings may not accurately reflect the level of chloramphenicol resistance by cat-bearing bacteria in vivo. | Chloramphenicol | chloramphenicol acetyltransferase | Escherichia coli |