Title : Control of erythropoietin secretion by doxycycline or mifepristone in mice bearing polymer-encapsulated engineered cells.

Pub. Date : 1999 Feb 10

PMID : 10048390






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Control of erythropoietin secretion by doxycycline or mifepristone in mice bearing polymer-encapsulated engineered cells. Doxycycline erythropoietin Mus musculus
2 We generated populations of immortalized murine NIH 3T3 fibroblasts that secrete mouse erythropoietin (Epo) in response to stimulation by doxycycline or mifepristone. Doxycycline erythropoietin Mus musculus
3 We generated populations of immortalized murine NIH 3T3 fibroblasts that secrete mouse erythropoietin (Epo) in response to stimulation by doxycycline or mifepristone. Doxycycline erythropoietin Mus musculus
4 Animals receiving doxycycline or mifepristone showed stable polyhemia and increased serum Epo concentrations over a 6-month observation period, whereas animals not receiving the inducer drug had normal hematocrits. Doxycycline erythropoietin Mus musculus
5 Epo secretion could be switched on and off, depending on the presence of doxycycline in the drinking water. Doxycycline erythropoietin Mus musculus