Title : Resistance of central phenylethanolamine-n-methyl transferase containing neurons to 6-hydroxydopamine.

Pub. Date : 1976 Dec

PMID : 1004027






3 Functional Relationships(s)
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1 The effects of the catecholamine neurotoxin 6-hydroxydopamine on phenylethanolamine-N-methyl transferase (PNMT) in rat brain has been investigated by biochemical and immunohistochemical analysis. Catecholamines phenylethanolamine-N-methyltransferase Rattus norvegicus
2 The effects of the catecholamine neurotoxin 6-hydroxydopamine on phenylethanolamine-N-methyl transferase (PNMT) in rat brain has been investigated by biochemical and immunohistochemical analysis. Catecholamines phenylethanolamine-N-methyltransferase Rattus norvegicus
3 The present results show that the PNMT neurons are resistant to the neurotoxic action of 6-hydroxydopamine, possibly due to lack of catecholamine uptake mechanism or due to these neurons having an uptake mechanism with a low affinity for 6-OH-DA. Catecholamines phenylethanolamine-N-methyltransferase Rattus norvegicus