Title : ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements.

Pub. Date : 1999 Mar

PMID : 10036235






2 Functional Relationships(s)
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1 Cells expressing wild-type ARF6 or Rac1 formed actin-containing surface protrusions and membrane ruffles, respectively, upon treatment with the G protein activator aluminum fluoride. aluminum fluoride ADP ribosylation factor 6 Homo sapiens
2 Co-expression of the dominant negative, GTP binding-defective ARF6 T27N mutant inhibited the aluminum fluoride-induced ruffling observed in cells expressing Rac1, and the constitutive ruffling observed in cells expressing the activated Rac1 Q61L mutant. aluminum fluoride ADP ribosylation factor 6 Homo sapiens