Pub. Date : 1999 Mar
PMID : 10029619
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Because tumor necrosis factor (TNF)-alpha is important in the pathogenesis of inflammatory bowel disease, we investigated the effect of mesalamine on TNF-alpha-regulated signal transduction and proliferation in intestinal epithelial cells. | Mesalamine | tumor necrosis factor | Mus musculus |
| 2 | RESULTS: The antiproliferative effects of TNF-alpha were blocked by mesalamine. | Mesalamine | tumor necrosis factor | Mus musculus |
| 3 | TNF-alpha and ceramide activation of MAP kinase were inhibited by mesalamine, whereas epidermal growth factor activation of MAP kinase was unaffected. | Mesalamine | tumor necrosis factor | Mus musculus |
| 4 | TNF-alpha-stimulated NF-kappaB activation and nuclear translocation and the degradation of Ikappa-Balpha were blocked by mesalamine. | Mesalamine | tumor necrosis factor | Mus musculus |
| 5 | CONCLUSIONS: Mesalamine inhibits TNF-alpha-mediated effects on intestinal epithelial cell proliferation and activation of MAP kinase and NF-kappaB. | Mesalamine | tumor necrosis factor | Mus musculus |