Pub. Date : 1999 Feb
PMID : 10029158
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | IL-1beta mediates diethyldithiocarbamate-induced granulocyte colony-stimulating factor production and hematopoiesis. | Ditiocarb | interleukin 1 beta | Homo sapiens |
| 2 | The mechanism of DDTC-mediated chemoprotection is believed to involve the induction and release of several cytokines, including interleukin-1 beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and granulocyte colony-stimulating factor (G-CSF). | Ditiocarb | interleukin 1 beta | Homo sapiens |
| 3 | The mechanism of DDTC-mediated chemoprotection is believed to involve the induction and release of several cytokines, including interleukin-1 beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and granulocyte colony-stimulating factor (G-CSF). | Ditiocarb | interleukin 1 beta | Homo sapiens |
| 4 | Administration of IL-1 receptor antagonist (IL-1ra) to DDTC-treated hLTBMCs obviated the G-CSF induction profile and blocked the resultant colony proliferation, indicating that IL-1beta mediates DDTC-induced G-CSF release and hematopoiesis. | Ditiocarb | interleukin 1 beta | Homo sapiens |
| 5 | Administration of IL-1 receptor antagonist (IL-1ra) to DDTC-treated hLTBMCs obviated the G-CSF induction profile and blocked the resultant colony proliferation, indicating that IL-1beta mediates DDTC-induced G-CSF release and hematopoiesis. | Ditiocarb | interleukin 1 beta | Homo sapiens |
| 6 | IL-1beta mRNA levels were increased threefold over control following DDTC treatment of hLTBMCs, implying that DDTC induces IL-1beta at the level of transcription. | Ditiocarb | interleukin 1 beta | Homo sapiens |
| 7 | IL-1beta mRNA levels were increased threefold over control following DDTC treatment of hLTBMCs, implying that DDTC induces IL-1beta at the level of transcription. | Ditiocarb | interleukin 1 beta | Homo sapiens |
| 8 | IL-1beta mRNA levels were increased threefold over control following DDTC treatment of hLTBMCs, implying that DDTC induces IL-1beta at the level of transcription. | Ditiocarb | interleukin 1 beta | Homo sapiens |
| 9 | IL-1beta mRNA levels were increased threefold over control following DDTC treatment of hLTBMCs, implying that DDTC induces IL-1beta at the level of transcription. | Ditiocarb | interleukin 1 beta | Homo sapiens |
| 10 | These findings taken together strongly suggest that IL-1beta mediates the chemoprotective effects of DDTC. | Ditiocarb | interleukin 1 beta | Homo sapiens |