Title : Relaxation of endothelin-1-induced pulmonary arterial constriction by niflumic acid and NPPB: mechanism(s) independent of chloride channel block.

Pub. Date : 1999 Mar

PMID : 10027865






2 Functional Relationships(s)
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1 When L-type Ca++ channels were blocked by nifedipine (10 microM), the ET-1-induced (30 nM) constriction was inhibited by only 5.8%. Nifedipine endothelin 1 Rattus norvegicus
2 However, niflumic acid (30 microM) and NPPB (30 microM) inhibited the ET-1-induced constriction by approximately 53% and approximately 60%, respectively, both in the continued presence of nifedipine and in Ca++-free physiological salt solution. Nifedipine endothelin 1 Rattus norvegicus