Title : Highly sensitive high-performance liquid chromatographic assay for coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human liver cytochrome P450 enzymes.

Pub. Date : 1999 Jan 8

PMID : 10027632






1 Functional Relationships(s)
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1 With 36 different substrate concentrations in these two reactions, coumarin 7-hydroxylation was found to be catalyzed mainly by a single enzyme CYP2A6 and 7-ethoxycoumarin was oxidized by at least two enzymes CYP2E1 and CYP1A2 in human liver microsomes. coumarin cytochrome P450 family 2 subfamily E member 1 Homo sapiens