Pub. Date : 1999 Jan 28
PMID : 10023685
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop. | Etoposide | MDM2 proto-oncogene | Homo sapiens |
| 2 | Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop. | Etoposide | MDM2 proto-oncogene | Homo sapiens |
| 3 | Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop. | Etoposide | MDM2 proto-oncogene | Homo sapiens |
| 4 | Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop. | Etoposide | MDM2 proto-oncogene | Homo sapiens |
| 5 | We show here that the topoisomerase poison etoposide, like ultra violet irradiation, inhibits Mdm2 synthesis. | Etoposide | MDM2 proto-oncogene | Homo sapiens |
| 6 | Cytotoxic concentrations of etoposide (IC90 for > 3 h) result in inhibition of Mdm2 induction at both the RNA and protein level. | Etoposide | MDM2 proto-oncogene | Homo sapiens |
| 7 | Inhibition of Mdm2 synthesis depends on the continuous presence of etoposide, suggesting the DNA damage may prevent transcription. | Etoposide | MDM2 proto-oncogene | Homo sapiens |
| 8 | When cells are -treated with a pulse (1 h) of etoposide and reincubated in drug free medium, Mdm2 synthesis commences immediately after damage is repaired (3 h) and the p53 response is attenuated. | Etoposide | MDM2 proto-oncogene | Homo sapiens |