| 1 |
34668334 | Physiologically-based pharmacokinetic modeling to evaluate in vitro-to-in vivo extrapolation for intestinal P-glycoprotein inhibition. | 2022 Jan |
4 |
| 2 |
34903589 | Transplacental Pharmacokinetic Model of Digoxin Based on Ex Vivo Human Placental Perfusion Study. | 2022 Mar |
1 |
| 3 |
35570332 | Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P-glycoprotein induction and inhibition in the intestine, liver, and kidney. | 2022 May 15 |
2 |
| 4 |
35616006 | Pharmacokinetics of asciminib in the presence of CYP3A or P-gp inhibitors, CYP3A inducers, and acid-reducing agents. | 2022 May 26 |
1 |
| 5 |
34009624 | Analysis of Non-linear Pharmacokinetics of P-Glycoprotein Substrates in a Microfluidic Device Using a Mathematical Model that Includes an Unstirred Water Layer (UWL) Compartment. | 2021 Jun |
3 |
| 6 |
34268580 | Differences in P-glycoprotein activity in human and rodent blood-brain barrier assessed by mechanistic modelling. | 2021 Sep |
1 |
| 7 |
29806615 | Development of a Microfluidic System Comprising Dialysis and Secretion Components for a Bioassay of Renal Clearance. | 2018 Sep 10 |
2 |
| 8 |
29521222 | Evaluation of Drug Transport in MDCKII-Wild Type, MDCKII-MDR1, MDCKII-BCRP and Caco-2 Cell Lines. | 2017 |
3 |
| 9 |
26248047 | The effect of quinidine, a strong P-glycoprotein inhibitor, on the pharmacokinetics and central nervous system distribution of naloxegol. | 2016 Apr |
3 |
| 10 |
26995013 | In vitro and in vivo evaluations of the P-glycoprotein-mediated efflux of dibenzoylhydrazines. | 2016 May 1 |
3 |
| 11 |
27262425 | Structure-activity relationships of dibenzoylhydrazines for the inhibition of P-glycoprotein-mediated quinidine transport. | 2016 Jul 15 |
3 |
| 12 |
27652191 | Natural flavonoids silymarin and quercetin improve the brain distribution of co-administered P-gp substrate drugs. | 2016 |
1 |
| 13 |
25901027 | Circadian modulation in the intestinal absorption of P-glycoprotein substrates in monkeys. | 2015 Jul |
2 |
| 14 |
24212378 | In vitro predictability of drug-drug interaction likelihood of P-glycoprotein-mediated efflux of dabigatran etexilate based on [I]2/IC50 threshold. | 2014 Feb |
2 |
| 15 |
25168620 | Edoxaban population pharmacokinetics and exposure-response analysis in patients with non-valvular atrial fibrillation. | 2014 Nov |
1 |
| 16 |
23435914 | Menadione serves as a substrate for P-glycoprotein: implication in chemosensitizing activity. | 2013 Apr |
1 |
| 17 |
23784266 | Drug-drug interaction studies of cardiovascular drugs involving P-glycoprotein, an efflux transporter, on the pharmacokinetics of edoxaban, an oral factor Xa inhibitor. | 2013 Oct |
1 |
| 18 |
21484807 | Substrate- and species-dependent inhibition of P-glycoprotein-mediated transport: implications for predicting in vivo drug interactions. | 2011 Aug |
1 |
| 19 |
21716273 | Nonlinear pharmacokinetics of oral quinidine and verapamil in healthy subjects: a clinical microdosing study. | 2011 Aug |
2 |
| 20 |
19631272 | Xenopus laevis oocytes expressing human P-glycoprotein: probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux. | 2010 Jan |
2 |
| 21 |
19816852 | Development and validation of RP-HPLC-fluorescence method for quantitative determination of quinidine, a probe substrate for P-glycoprotein inhibition assay using Caco-2 cell monolayer. | 2010 Jun |
4 |
| 22 |
20135207 | Model analysis of the concentration-dependent permeability of P-gp substrates. | 2010 Mar |
4 |
| 23 |
20163161 | Effects of experimental setup on the apparent concentration dependency of active efflux transport in in vitro cell permeation experiments. | 2010 Apr 5 |
3 |
| 24 |
20214407 | Evaluation of in vivo P-glycoprotein phenotyping probes: a need for validation. | 2010 Apr |
1 |
| 25 |
18945821 | Inhibition of P-glycoprotein-mediated paclitaxel resistance by reversibly linked quinine homodimers. | 2009 Jan |
1 |
| 26 |
19122284 | Involvement of P-glycoprotein and multidrug resistance associated protein 1 on the transepithelial transport of a mercaptoacetamide-based histone-deacetylase inhibitor in Caco-2 cells. | 2009 Jan |
1 |
| 27 |
17967933 | Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells. | 2008 Feb |
4 |
| 28 |
18057117 | In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier. | 2008 Mar |
1 |
| 29 |
18668443 | Validation and application of Caco-2 assays for the in vitro evaluation of development candidate drugs as substrates or inhibitors of P-glycoprotein to support regulatory submissions. | 2008 Jul |
1 |
| 30 |
18703021 | Induction of P-glycoprotein expression and function in human intestinal epithelial cells (T84). | 2008 Oct 1 |
2 |
| 31 |
18718123 | Presence or absence of a gallate moiety on catechins affects their cellular transport. | 2008 Sep |
2 |
| 32 |
17094122 | Species differences of inhibitory effects on P-glycoprotein-mediated drug transport. | 2007 Jun |
4 |
| 33 |
17548462 | Decrease in intracellular concentration causes the shift in Km value of efflux pump substrates. | 2007 Sep |
1 |
| 34 |
17713975 | Increased absorption of digoxin from the human jejunum due to inhibition of intestinal transporter-mediated efflux. | 2007 |
3 |
| 35 |
16406207 | Development, validation and utility of an in vitro technique for assessment of potential clinical drug-drug interactions involving P-glycoprotein. | 2006 Apr |
1 |
| 36 |
16647797 | Effect of benzo[a]pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer. | 2006 Jun 1 |
1 |
| 37 |
14973303 | Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl. | 2004 Mar |
3 |
| 38 |
15089813 | The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone. | 2004 May |
1 |
| 39 |
15229466 | Substantial pharmacokinetic interaction between digoxin and ritonavir in healthy volunteers. | 2004 Jul |
1 |
| 40 |
15981588 | Circumventing P-glycoprotein-mediated cellular efflux of quinidine by prodrug derivatization. | 2004 Jul-Aug |
5 |
| 41 |
12621387 | P-glycoprotein-mediated intestinal and biliary digoxin transport in humans. | 2003 Mar |
1 |
| 42 |
12649369 | Inhibition of P-glycoprotein by newer antidepressants. | 2003 Apr |
1 |
| 43 |
12948010 | pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions. | 2003 Aug |
2 |
| 44 |
12948013 | Quantitative evaluation of the function of small intestinal P-glycoprotein: comparative studies between in situ and in vitro. | 2003 Aug |
1 |
| 45 |
12948018 | Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers. | 2003 Aug |
1 |
| 46 |
14534517 | Respiratory and miotic effects of morphine in healthy volunteers when P-glycoprotein is blocked by quinidine. | 2003 Oct |
3 |
| 47 |
14583678 | Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers. | 2003 Nov |
1 |
| 48 |
14663457 | Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine. | 2003 Dec |
1 |
| 49 |
11821009 | A co-culture-based model of human blood-brain barrier: application to active transport of indinavir and in vivo-in vitro correlation. | 2002 Feb 15 |
2 |
| 50 |
11336351 | A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function. | 2001 Jan |
1 |