Bortezomib

MYC proto-oncogene, bHLH transcription factor ; Homo sapiens







27 Article(s)
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1 33938943 G9a/GLP targeting in MM promotes autophagy-associated apoptosis and boosts proteasome inhibitor-mediated cell death. 2021 May 11 1
2 32235770 Upregulation of Protein Synthesis and Proteasome Degradation Confers Sensitivity to Proteasome Inhibitor Bortezomib in Myc-Atypical Teratoid/Rhabdoid Tumors. 2020 Mar 22 3
3 32724371 Effect of bortezomib on proliferation and apoptosis of myeloma cells by activating Wnt/β-catenin signaling pathway. 2020 Aug 1
4 33099868 Targeting the ubiquitin-proteasome system in a pancreatic cancer subtype with hyperactive MYC. 2020 Dec 2
5 30837032 Synergistic Efficacy of the Demethylation Agent Decitabine in Combination With the Protease Inhibitor Bortezomib for Treating Multiple Myeloma Through the Wnt/β-Catenin Pathway. 2019 Jun 21 2
6 31406244 FDA-approved drug screen identifies proteasome as a synthetic lethal target in MYC-driven neuroblastoma. 2019 Oct 1
7 29472861 1,2,3,4,6-Penta-O-Galloyl-Beta-D-Glucopyranoside Inhibits Proliferation of Multiple Myeloma Cells Accompanied with Suppression of MYC Expression. 2018 1
8 28000897 Bortezomib induces apoptosis and suppresses cell growth and metastasis by inactivation of Stat3 signaling in chondrosarcoma. 2017 Feb 1
9 26667773 Comparison of antiproliferative and apoptotic effects of a novel proteasome inhibitor MLN2238 with bortezomib on K562 chronic myeloid leukemia cells. 2016 2
10 26683226 MTDH is an oncogene in multiple myeloma, which is suppressed by Bortezomib treatment. 2016 Jan 26 1
11 26740054 Signaling mechanisms of bortezomib in TRAF3-deficient mouse B lymphoma and human multiple myeloma cells. 2016 Feb 2
12 26317903 Bortezomib inhibits Burkitt's lymphoma cell proliferation by downregulating sumoylated hnRNP K and c-Myc expression. 2015 Sep 22 3
13 26378933 Deletion of Chromosomal Region 8p21 Confers Resistance to Bortezomib and Is Associated with Upregulated Decoy TRAIL Receptor Expression in Patients with Multiple Myeloma. 2015 1
14 24104394 MicroRNA187 overexpression is related to tumor progression and determines sensitivity to bortezomib in peripheral T-cell lymphoma. 2014 Apr 2
15 24496825 Impact of C-Myc gene-related aberrations in newly diagnosed myeloma with bortezomib/dexamethasone therapy. 2014 Mar 1
16 25147211 MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib. 2014 2
17 23527180 cMyc/miR-125b-5p signalling determines sensitivity to bortezomib in preclinical model of cutaneous T-cell lymphomas. 2013 3
18 23536725 Profiling bortezomib resistance identifies secondary therapies in a mouse myeloma model. 2013 Jun 1
19 23612979 Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response. 2013 May 31 3
20 21297663 Myc overexpression brings out unexpected antiapoptotic effects of miR-34a. 2011 Jun 2 1
21 21468039 Clinical and biological implications of MYC activation: a common difference between MGUS and newly diagnosed multiple myeloma. 2011 Jun 1
22 20460535 Genome-wide siRNA screen for modulators of cell death induced by proteasome inhibitor bortezomib. 2010 Jun 1 1
23 20615981 Efficacy of bortezomib in a direct xenograft model of primary effusion lymphoma. 2010 Jul 20 1
24 18235046 PRDM1 is involved in chemoresistance of T-cell lymphoma and down-regulated by the proteasome inhibitor. 2008 Apr 1 1
25 18544564 Hypoxia-inducible factor-2alpha regulates the expression of TRAIL receptor DR5 in renal cancer cells. 2008 Sep 3
26 18641367 Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA. 2008 Oct 1 8
27 18042711 Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition. 2007 Dec 4 1