2-piperidone

tumor protein p53 ; Homo sapiens







8 Article(s)
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PMID
Title
Pub. Year
#Total Relationships
1 30253242 The development of piperidinones as potent MDM2-P53 protein-protein interaction inhibitors for cancer therapy. 2018 Nov 5 4
2 24456472 Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development. 2014 Feb 27 1
3 24548297 Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction. 2014 Mar 27 1
4 24601644 Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres. 2014 Apr 10 1
5 24967612 Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer. 2014 Aug 14 1
6 25042256 Optimization beyond AMG 232: discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction. 2014 Aug 15 2
7 25384157 Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction. 2014 Dec 26 1
8 22991965 Ordering of the N-terminus of human MDM2 by small molecule inhibitors. 2012 Oct 17 1