Doxorubicin

mitogen-activated protein kinase 1 ; Homo sapiens







79 Article(s)
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1 34783124 Ginsenoside RG1 augments doxorubicin-induced apoptotic cell death in MDA-MB-231 breast cancer cell lines. 2022 Jan 1
2 35039569 Mutated RAS-associating proteins and ERK activation in relapse/refractory diffuse large B cell lymphoma. 2022 Jan 17 1
3 35209071 Inhibitory Effect of Ursolic Acid on the Migration and Invasion of Doxorubicin-Resistant Breast Cancer. 2022 Feb 14 1
4 35395977 [Effect of Doxycycline on Intrinsic Apoptosis of Myeloma Cell Line H929 and Its Mechanism]. 2022 Apr 1
5 33115283 Combination treatment strategies with a focus on rosiglitazone and adriamycin for insulin resistant liver cancer. 2021 Mar 1
6 33771646 Calcium channel blockers lercanidipine and amlodipine inhibit YY1/ERK/TGF-β mediated transcription and sensitize the gastric cancer cells to doxorubicin. 2021 Aug 2
7 34119884 Urinary exosomes-based Engineered Nanovectors for Homologously Targeted Chemo-Chemodynamic Prostate Cancer Therapy via abrogating EGFR/AKT/NF-kB/IkB signaling. 2021 Aug 1
8 34232382 Eukaryotic initiation factor-2, gamma subunit, suppresses proliferation and regulates the cell cycle via the MAPK/ERK signaling pathway in acute myeloid leukemia. 2021 Nov 2
9 34238921 Implication of human endogenous retrovirus W family envelope in hepatocellular carcinoma promotes MEK/ERK-mediated metastatic invasiveness and doxorubicin resistance. 2021 Jul 8 1
10 34520240 Retraction of: miR-132 Regulates Adriamycin Resistance in Colorectal Cancer Cells Through Targeting Extracellular Signal-Regulated Kinase 1 (doi: 10.1089/cbr.2018.2749). 2021 Oct 1
11 34589399 Combination therapy with miR34a and doxorubicin synergistically inhibits Dox-resistant breast cancer progression via down-regulation of Snail through suppressing Notch/NF-κB and RAS/RAF/MEK/ERK signaling pathway. 2021 Sep 3
12 31843629 Parameritannin A-2 from Urceola huaitingii enhances doxorubicin-induced mitochondria-dependent apoptosis by inhibiting the PI3K/Akt, ERK1/2 and p38 pathways in gastric cancer cells. 2020 Jan 25 4
13 32354131 Early Moderate Intensity Aerobic Exercise Intervention Prevents Doxorubicin-Caused Cardiac Dysfunction Through Inhibition of Cardiac Fibrosis and Inflammation. 2020 Apr 28 1
14 32459053 BRD2 induces drug resistance through activation of the RasGRP1/Ras/ERK signaling pathway in adult T-cell lymphoblastic lymphoma. 2020 Jun 1
15 32722178 The Long-Lasting Protective Effect of HGF in Cardiomyoblasts Exposed to Doxorubicin Requires a Positive Feed-Forward Loop Mediated by Erk1,2-Timp1-Stat3. 2020 Jul 24 1
16 32818507 EGCG sensitizes chemotherapeutic-induced cytotoxicity by targeting the ERK pathway in multiple cancer cell lines. 2020 Oct 15 1
17 31356549 Curdione Ameliorated Doxorubicin-Induced Cardiotoxicity Through Suppressing Oxidative Stress and Activating Nrf2/HO-1 Pathway. 2019 Aug 1
18 31377057 Inhibition of the ERK1/2-mTORC1 axis ameliorates proteinuria and the fibrogenic action of transforming growth factor-β in Adriamycin-induced glomerulosclerosis. 2019 Oct 1
19 28295305 Mitochondrial ROS-induced ERK1/2 activation and HSF2-mediated AT1 R upregulation are required for doxorubicin-induced cardiotoxicity. 2018 Jan 2
20 29108991 SETDB1-mediated FosB regulation via ERK2 is associated with an increase in cell invasiveness during anticancer drug treatment of A549 human lung cancer cells. 2018 Jan 1 1
21 29307829 Blockage of cytosolic phospholipase A2 alpha sensitizes aggressive breast cancer to doxorubicin through suppressing ERK and mTOR kinases. 2018 Jan 29 1
22 29574069 Forskolin improves sensitivity to doxorubicin of triple negative breast cancer cells via Protein Kinase A-mediated ERK1/2 inhibition. 2018 Jun 2
23 30230033 Amphiregulin enhances cell migration and resistance to doxorubicin in chondrosarcoma cells through the MAPK pathway. 2018 Dec 1
24 27649518 Inhibition of the PI3K/AKT Pathway Sensitizes Oral Squamous Cell Carcinoma Cells to Anthracycline-Based Chemotherapy In Vitro. 2017 Sep 2
25 28027688 Silibinin sensitizes chemo-resistant breast cancer cells to chemotherapy. 2017 Dec 1
26 28098907 Synergistic combination of YS-1 and adriamycin inhibits human renal cancer through ERK1/2 signaling pathway in vitro and in vivo. 2017 Mar 4
27 28229963 Constitutively activated ERK sensitizes cancer cells to doxorubicin: Involvement of p53-EGFR-ERK pathway. 2017 Mar 3
28 28793338 Anti-tumor activity of nanomicelles encapsulating CXCR4 peptide antagonist E5. 2017 2
29 28923539 Efficient VEGF targeting delivery of DOX using Bevacizumab conjugated SiO2@LDH for anti-neuroblastoma therapy. 2017 Nov 1
30 28988530 Hyperexpression of Integrin α5β1 Promotes Resistance of MCF-7 Human Breast Carcinoma Cells to Doxorubicin via ERK Protein Kinase Down-regulation. 2017 Sep 2
31 29061787 (-)-Epigallocatechin-3-gallate Down-regulates Doxorubicin-induced Overexpression of P-glycoprotein Through the Coordinate Inhibition of PI3K/Akt and MEK/ERK Signaling Pathways. 2017 Nov 3
32 26842910 MiR-302a/b/c/d cooperatively sensitizes breast cancer cells to adriamycin via suppressing P-glycoprotein(P-gp) by targeting MAP/ERK kinase kinase 1 (MEKK1). 2016 Feb 3 1
33 25742496 Correction: Urotensin II inhibits doxorubicin-induced human umbilical vein endothelial cell death by modulating ATF expression and via the ERK and Akt pathway. 2015 1
34 24407515 Inhibition of GSK-3β activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in MCF-7 breast cancer cells. 2014 1
35 24797310 Strategy to enhance the therapeutic effect of doxorubicin in human hepatocellular carcinoma by selenocystine, a synergistic agent that regulates the ROS-mediated signaling. 2014 May 15 1
36 24830744 Evodiamine synergizes with doxorubicin in the treatment of chemoresistant human breast cancer without inhibiting P-glycoprotein. 2014 1
37 25043687 Down-regulation of the P-glycoprotein relevant for multidrug resistance by intracellular acidification through the crosstalk of MAPK signaling pathways. 2014 Sep 1
38 25268131 Urotensin II inhibits doxorubicin-induced human umbilical vein endothelial cell death by modulating ATF expression and via the ERK and Akt pathway. 2014 2
39 23320839 MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma. 2013 Jan 15 2
40 23994249 Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway. 2013 Oct 25 1
41 24147064 Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: a mitochondrial division/mitophagy inhibitor. 2013 1
42 24217648 Doxorubicin caused apoptosis of mesenchymal stem cells via p38, JNK and p53 pathway. 2013 1
43 22429871 A 43 kD protein from the leaves of the herb Cajanus indicus L. modulates doxorubicin induced nephrotoxicity via MAPKs and both mitochondria dependent and independent pathways. 2012 Jun 1
44 22457358 α2β1 integrin promotes chemoresistance against doxorubicin in cancer cells through extracellular signal-regulated kinase (ERK). 2012 May 18 3
45 22469513 Mitochondrial superoxide mediates doxorubicin-induced keratinocyte apoptosis through oxidative modification of ERK and Bcl-2 ubiquitination. 2012 Jun 15 1
46 22493363 Treatment of breast cancer cells by IGF1R tyrosine kinase inhibitor combined with conventional systemic drugs. 2012 Apr 1
47 22576950 Midkine confers Adriamycin resistance in human gastric cancer cells. 2012 Oct 6
48 22787275 Collagen/β1 integrin signaling up-regulates the ABCC1/MRP-1 transporter in an ERK/MAPK-dependent manner. 2012 Sep 2
49 23028726 Doxorubicin induces cytotoxicity through upregulation of pERK-dependent ATF3. 2012 3
50 23493035 Different Expression of Extracellular Signal-Regulated Kinases (ERK) 1/2 and Phospho-Erk Proteins in MBA-MB-231 and MCF-7 Cells after Chemotherapy with Doxorubicin or Docetaxel. 2012 Jan 4