Bortezomib

RELA proto-oncogene, NF-kB subunit ; Homo sapiens







27 Article(s)
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1 34719869 Bortezomib is significantly beneficial for de novo pediatric AML patients with low phosphorylation of the NF-κB subunit RelA. 2022 Mar 3
2 33406639 Activation of Serum/Glucocorticoid Regulated Kinase 1/Nuclear Factor-κB Pathway Are Correlated with Low Sensitivity to Bortezomib and Ixazomib in Resistant Multiple Myeloma Cells. 2021 Jan 4 1
3 29441489 Pirh2 mediates the sensitivity of myeloma cells to bortezomib via canonical NF-κB signaling pathway. 2018 Sep 1
4 26593250 Synergistic cytotoxic effects of bortezomib and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB. 2016 Jan 12 1
5 26743692 TrxR1 inhibition overcomes both hypoxia-induced and acquired bortezomib resistance in multiple myeloma through NF-кβ inhibition. 2016 1
6 25565020 Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma. 2015 6
7 25661379 Blocking NF-κB sensitizes non-small cell lung cancer cells to histone deacetylase inhibitor induced extrinsic apoptosis through generation of reactive oxygen species. 2015 Feb 2
8 25766331 NIK is required for NF-κB-mediated induction of BAG3 upon inhibition of constitutive protein degradation pathways. 2015 Mar 12 1
9 25895124 Anti-β₂-microglobulin monoclonal antibodies overcome bortezomib resistance in multiple myeloma by inhibiting autophagy. 2015 Apr 20 1
10 26431276 Bortezomib enhances expression of effector molecules in anti-tumor CD8+ T lymphocytes by promoting Notch-nuclear factor-κB crosstalk. 2015 Oct 20 1
11 26494122 Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity. 2015 Dec 15 1
12 24481412 IKKβ inhibitor in combination with bortezomib induces cytotoxicity in breast cancer cells. 2014 Apr 1
13 24908318 Chromatin immunoprecipitation analysis of bortezomib-mediated inhibition of NFκB recruitment to IL-1β and TNFα gene promoters in human macrophages. 2014 2
14 25089799 Bcl3 regulates pro-survival and pro-inflammatory gene expression in cutaneous T-cell lymphoma. 2014 Nov 2
15 23276925 BlyS: a potential hallmark of multiple myeloma. 2013 Jan 1 1
16 23894194 Proteasome inhibition by bortezomib increases IL-8 expression in androgen-independent prostate cancer cells: the role of IKKα. 2013 Sep 1 3
17 22819259 Blockade of NFκB activity by Sunitinib increases cell death in Bortezomib-treated endometrial carcinoma cells. 2012 Oct 3
18 23048077 Mechanisms of activity of the TORC1 inhibitor everolimus in Waldenstrom macroglobulinemia. 2012 Dec 15 1
19 21220502 Bortezomib sensitizes malignant human glioma cells to TRAIL, mediated by inhibition of the NF-{kappa}B signaling pathway. 2011 Jan 3
20 21729550 [Effect of curcumin in combination with bortezomib on proliferation and apoptosis of human multiple myeloma cell line H929 and its mechanism]. 2011 Jun 1
21 20335171 Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IkappaB(alpha) degradation. 2010 May 21 1
22 20651335 Bortezomib therapeutic effect is associated with expression and mutation of FGFR3 in human lymphoma cells. 2010 Jun 1
23 20046572 Combination bortezomib and rituximab treatment affects multiple survival and death pathways to promote apoptosis in mantle cell lymphoma. 2009 Jan-Feb 1
24 18593997 Bortezomib-induced apoptosis with limited clinical response is accompanied by inhibition of canonical but not alternative nuclear factor-{kappa}B subunits in head and neck cancer. 2008 Jul 1 2
25 18776064 Bortezomib-induced survival signals and genes in human proximal tubular cells. 2008 Dec 1
26 17237265 Nuclear factor-kappaB p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor PXD101. 2007 Jan 1
27 15210859 Maximal apoptosis of renal cell carcinoma by the proteasome inhibitor bortezomib is nuclear factor-kappaB dependent. 2004 Jun 2